About Us
Shanghai Juncell Therapeutics Co., Ltd. (Juncell Therapeutics) was established in 2019. It is a biotechnology company dedicated to the innovation and development of novel cell therapies and drugs for the treatment of solid tumors. We focus on developing safer, more effective, more accessible and more affordable immune cell therapies that are not constrained by any fixed molecular targets and are designed to address both the most prevalent and the most refractory solid tumors.
Leveraging our proprietary DeepTIL™ cell enrichment expansion platform, NovaGMP™ non-viral gene-modification platform and RiverTIL™ in vivo TIL platform, we have established a strong technological foundation for continuously developing a pipeline of first-in-class and best-in-class natural and gene-modified TIL therapies.
GC101, is the world's first TIL therapy that does not require high-intensity lymphodepletion chemotherapy or the use of IL-2 administration, has brought long-term benefits to patients with advanced metastatic solid tumors who failed multiple lines of treatment, including melanoma, non-small cell lung cancer, cervical cancer, endometrial cancer, pancreatic cancer and glioma. Multiple patients have achieved complete tumor clearance, with the longest tumor-free survival exceeding four years.
Core Technology
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DeepTILTM Cell Enrichment Expansion Platform
☛ Clinical-grade TILs can be obtained with a high successful rate.
☛ TIL cell culture does not rely on healthy human PBMC as feeder cells, resulting in a simpler process and lower cost.
☛ Free from high-intensity lymphodepletion chemotherapy and IL-2 administration, and patients can be treated in less demanding wards, with improved safety.
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NovaGMPTM Non-viral Gene Modification Platform
☛ Non-viral gene modification. No risk of wild-type virus mutations.
☛ The cost of non-viral vector-based gene modification is substantially reduced compared with that of viral vectors system.
☛ Average gene modification efficiency >45%, Average viability after modification >90%.
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RiverTILTM In Vivo TIL Platform
☛ Pre-manufacture and cryopreserve TIL seed cells from a patient's resected tumor tissue for future on-demand use.
☛ Rapid in vivo expansion and reaction after seed TIL infusion
☛ Significantly reducing manufacturing costs and production time.
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Robust
Reproducible performance across over 30 types of solid tumors.
Culture success rate >95%
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Competent
The average number of cells is approximately 20 billion,
IL-2 administration free
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Affordable
Substantial reduction in manufacturing costs and overall treatment costs
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Accessible
Patients treated in less demanding wards, and the time to reach discharge criteria is shortened
Clinical Trials
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A Phase II Trial of GC101 TIL in Advanced Melanoma(MIZAR-003)Beijing Cancer Hospital, Fujian Cancer Hospital, Fudan University Shanghai Cancer Center, Zhejiang Cancer hospital, Hunan Cancer Hospital, Henan Cancer Hospital, Cancer Hospital of Shandong First Medical University, etc.. -
A Phase Ib Trial of GC101 TIL in NSCLC(MIZAR-005)Shanghai Chest Hospital, Anhui Chest hospital, Hunan Cancer Hospital -
A Phase I Trial of GC203 TIL in Advanced Malignant Solid Tumors(KUNLUN-001)Fudan University Shanghai Cancer Center, Tianjin Medical University Cancer Institute & Hospital, Tenth People’s hospital of Tongji University, The Second Affiliated Hospital Zhejiang University School of Medicine, etc. -
A Phase I Trial of GC101 TIL in Advanced Malignant Solid TumorsChinese PLA General Hospital
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