Rebuild Cells, Rescue Lives

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Our Mission

Rebuild Cells, Rescue Lives

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Our Vision

Make Miracles Happen, Make Miracles Often

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Our Values

Concentration, Innovation, Inclusion, Collaboration

About Us

Shanghai Juncell Therapeutics Co., Ltd. (Juncell Therapeutics) was established in 2019. It is a biotechnology company dedicated to the innovation and development of novel cell therapies and drugs for the treatment of solid tumors. We focus on developing safer, more effective, more accessible and more affordable immune cell therapies that are not constrained by any fixed molecular targets and are designed to address both the most prevalent and the most refractory solid tumors. 


Leveraging our proprietary DeepTIL™ cell enrichment expansion platform, NovaGMP™ non-viral gene-modification platform and RiverTIL™ in vivo TIL platform, we have established a strong technological foundation for continuously developing a pipeline of first-in-class and best-in-class natural and gene-modified TIL therapies. 


GC101, is the world's first TIL therapy that does not require high-intensity lymphodepletion chemotherapy or the use of IL-2 administration, has brought long-term benefits to patients with advanced metastatic solid tumors who failed multiple lines of treatment, including melanoma, non-small cell lung cancer, cervical cancer, endometrial cancer, pancreatic cancer and glioma. Multiple patients have achieved complete tumor clearance, with the longest tumor-free survival exceeding four years.


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Core Technology

  • DeepTILTM Cell Enrichment Expansion Platform

    ☛ Clinical-grade TILs can be obtained with a high successful rate.

    ☛ TIL cell culture does not rely on healthy human PBMC as feeder cells, resulting in a simpler process and lower cost.

    ☛ Free from high-intensity lymphodepletion chemotherapy and IL-2 administration, and patients can be treated in less demanding wards, with improved safety.

  • NovaGMPTM Non-viral Gene Modification Platform

    ☛ Non-viral gene modification. No risk of wild-type virus mutations. 

    ☛ The cost of non-viral vector-based gene modification is substantially reduced compared with that of viral vectors system.

    ☛ Average gene modification efficiency >45%, Average viability after modification >90%.

  • RiverTILTM In Vivo TIL Platform

    ☛ Pre-manufacture and cryopreserve TIL seed cells from a patient's resected tumor tissue for future on-demand use.

    ☛ Rapid in vivo expansion and reaction after seed TIL infusion

    ☛ Significantly reducing manufacturing costs and production time.

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    Robust

    Reproducible performance across over 30 types of solid tumors. 

    Culture success rate >95%



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    Competent

    The average number of cells is approximately 20 billion,

    IL-2 administration free


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    Affordable

    Substantial reduction in manufacturing costs and overall treatment costs

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    Accessible

    Patients treated in less demanding wards, and the time to reach discharge criteria is shortened